diff --git a/src/api/environment.cc b/src/api/environment.cc
index 9ebc20223fe97e..4d991a35584a9f 100644
--- a/src/api/environment.cc
+++ b/src/api/environment.cc
@@ -958,7 +958,7 @@ MaybeLocal<Object> InitializePrivateSymbols(Local<Context> context,
 
   Local<Object> private_symbols_object;
   if (!private_symbols->NewInstance(context).ToLocal(&private_symbols_object) ||
-      private_symbols_object->SetPrototypeV2(context, Null(isolate))
+      private_symbols_object->SetPrototype(context, Null(isolate))
           .IsNothing()) {
     return MaybeLocal<Object>();
   }
@@ -984,7 +984,7 @@ MaybeLocal<Object> InitializePerIsolateSymbols(Local<Context> context,
   Local<Object> per_isolate_symbols_object;
   if (!per_isolate_symbols->NewInstance(context).ToLocal(
           &per_isolate_symbols_object) ||
-      per_isolate_symbols_object->SetPrototypeV2(context, Null(isolate))
+      per_isolate_symbols_object->SetPrototype(context, Null(isolate))
           .IsNothing()) {
     return MaybeLocal<Object>();
   }
diff --git a/src/internal_only_v8.cc b/src/internal_only_v8.cc
index 6a3c4e6952a8f3..487b8b7adfd356 100644
--- a/src/internal_only_v8.cc
+++ b/src/internal_only_v8.cc
@@ -33,8 +33,8 @@ class PrototypeChainHas : public v8::QueryObjectPredicate {
     if (creation_context != context_) {
       return false;
     }
-    for (Local<Value> proto = object->GetPrototypeV2(); proto->IsObject();
-         proto = proto.As<Object>()->GetPrototypeV2()) {
+    for (Local<Value> proto = object->GetPrototype(); proto->IsObject();
+         proto = proto.As<Object>()->GetPrototype()) {
       if (search_ == proto) return true;
     }
     return false;
diff --git a/src/js_native_api_v8.cc b/src/js_native_api_v8.cc
index d9e3cc66f8de2c..ef1d2743552b12 100644
--- a/src/js_native_api_v8.cc
+++ b/src/js_native_api_v8.cc
@@ -1585,7 +1585,7 @@ napi_status NAPI_CDECL node_api_set_prototype(napi_env env,
 
   v8::Local<v8::Value> val = v8impl::V8LocalValueFromJsValue(value);
 
-  v8::Maybe<bool> set_maybe = obj->SetPrototypeV2(context, val);
+  v8::Maybe<bool> set_maybe = obj->SetPrototype(context, val);
 
   RETURN_STATUS_IF_FALSE_WITH_PREAMBLE(
       env, set_maybe.FromMaybe(false), napi_generic_failure);
@@ -1604,7 +1604,7 @@ napi_status NAPI_CDECL napi_get_prototype(napi_env env,
   CHECK_TO_OBJECT(env, context, obj, object);
 
   // This doesn't invokes Proxy's [[GetPrototypeOf]] handler.
-  v8::Local<v8::Value> val = obj->GetPrototypeV2();
+  v8::Local<v8::Value> val = obj->GetPrototype();
   *result = v8impl::JsValueFromV8LocalValue(val);
   return GET_RETURN_STATUS(env);
 }
diff --git a/src/module_wrap.cc b/src/module_wrap.cc
index 70743ff6cd18ce..c6a0b0e703b949 100644
--- a/src/module_wrap.cc
+++ b/src/module_wrap.cc
@@ -1035,7 +1035,7 @@ void ModuleWrap::HasAsyncGraph(Local<Name> property,
   Isolate* isolate = args.GetIsolate();
   Environment* env = Environment::GetCurrent(isolate);
   ModuleWrap* obj;
-  ASSIGN_OR_RETURN_UNWRAP(&obj, args.HolderV2());
+  ASSIGN_OR_RETURN_UNWRAP(&obj, args.Holder());
 
   Local<Module> module = obj->module_.Get(isolate);
   if (module->GetStatus() < Module::kInstantiated) {
@@ -1251,7 +1251,7 @@ void ModuleWrap::SetImportMetaResolveInitializer(
 static void ImportMetaResolveLazyGetter(
     Local<v8::Name> name, const PropertyCallbackInfo<Value>& info) {
   Isolate* isolate = info.GetIsolate();
-  Local<Value> receiver_val = info.HolderV2();
+  Local<Value> receiver_val = info.Holder();
   if (!receiver_val->IsObject()) {
     THROW_ERR_INVALID_INVOCATION(isolate);
     return;
@@ -1292,7 +1292,7 @@ static void PathHelpersLazyGetter(Local<v8::Name> name,
   // When this getter is invoked in a vm context, the `Realm::GetCurrent(info)`
   // returns a nullptr and retrieve the creation context via `this` object and
   // get the creation Realm.
-  Local<Value> receiver_val = info.HolderV2();
+  Local<Value> receiver_val = info.Holder();
   if (!receiver_val->IsObject()) {
     THROW_ERR_INVALID_INVOCATION(isolate);
     return;
diff --git a/src/node_buffer.cc b/src/node_buffer.cc
index ba310268d80663..fd6bc52628994c 100644
--- a/src/node_buffer.cc
+++ b/src/node_buffer.cc
@@ -287,7 +287,7 @@ MaybeLocal<Uint8Array> New(Environment* env,
                            size_t length) {
   CHECK(!env->buffer_prototype_object().IsEmpty());
   Local<Uint8Array> ui = Uint8Array::New(ab, byte_offset, length);
-  if (ui->SetPrototypeV2(env->context(), env->buffer_prototype_object())
+  if (ui->SetPrototype(env->context(), env->buffer_prototype_object())
           .IsNothing()) {
     return MaybeLocal<Uint8Array>();
   }
diff --git a/src/node_constants.cc b/src/node_constants.cc
index 50ece35429e932..07eb5e671cb3ea 100644
--- a/src/node_constants.cc
+++ b/src/node_constants.cc
@@ -1284,7 +1284,7 @@ void CreatePerContextProperties(Local<Object> target,
   Isolate* isolate = Isolate::GetCurrent();
   Environment* env = Environment::GetCurrent(context);
 
-  CHECK(target->SetPrototypeV2(env->context(), Null(isolate)).FromJust());
+  CHECK(target->SetPrototype(env->context(), Null(isolate)).FromJust());
 
   Local<Object> os_constants =
       Object::New(isolate, Null(isolate), nullptr, nullptr, 0);
diff --git a/src/node_contextify.cc b/src/node_contextify.cc
index 066aa137676843..733c5845af98f1 100644
--- a/src/node_contextify.cc
+++ b/src/node_contextify.cc
@@ -454,7 +454,7 @@ ContextifyContext* ContextifyContext::Get(const PropertyCallbackInfo<T>& args) {
   // args.GetIsolate()->GetCurrentContext() and take the pointer at
   // ContextEmbedderIndex::kContextifyContext, as V8 is supposed to
   // push the creation context before invoking these callbacks.
-  return Get(args.HolderV2());
+  return Get(args.Holder());
 }
 
 ContextifyContext* ContextifyContext::Get(Local<Object> object) {
diff --git a/src/node_ffi.cc b/src/node_ffi.cc
index d0c578cfedd46a..67659e012fbdda 100644
--- a/src/node_ffi.cc
+++ b/src/node_ffi.cc
@@ -489,7 +489,7 @@ void DynamicLibrary::GetFunctions(const FunctionCallbackInfo<Value>& args) {
   }
 
   Local<Object> functions = Object::New(isolate);
-  if (!functions->SetPrototypeV2(context, Null(isolate)).FromMaybe(false)) {
+  if (!functions->SetPrototype(context, Null(isolate)).FromMaybe(false)) {
     return;
   }
 
@@ -645,7 +645,7 @@ void DynamicLibrary::GetSymbols(const FunctionCallbackInfo<Value>& args) {
   }
 
   Local<Object> symbols = Object::New(isolate);
-  if (!symbols->SetPrototypeV2(context, Null(isolate)).FromMaybe(false)) {
+  if (!symbols->SetPrototype(context, Null(isolate)).FromMaybe(false)) {
     return;
   }
   for (const auto& entry : lib->symbols_) {
diff --git a/src/node_options.cc b/src/node_options.cc
index a152d873052ff4..6dd7cdadbc149e 100644
--- a/src/node_options.cc
+++ b/src/node_options.cc
@@ -1830,8 +1830,7 @@ void GetCLIOptionsInfo(const FunctionCallbackInfo<Value>& args) {
 
   Local<Map> options = Map::New(isolate);
   if (options
-          ->SetPrototypeV2(context,
-                           env->primordials_safe_map_prototype_object())
+          ->SetPrototype(context, env->primordials_safe_map_prototype_object())
           .IsNothing()) {
     return;
   }
@@ -1871,8 +1870,7 @@ void GetCLIOptionsInfo(const FunctionCallbackInfo<Value>& args) {
   if (!ToV8Value(context, _ppop_instance.aliases_).ToLocal(&aliases)) return;
 
   if (aliases.As<Object>()
-          ->SetPrototypeV2(context,
-                           env->primordials_safe_map_prototype_object())
+          ->SetPrototype(context, env->primordials_safe_map_prototype_object())
           .IsNothing()) {
     return;
   }
diff --git a/src/node_sqlite.cc b/src/node_sqlite.cc
index 31803e1b06bf85..78f7f7f5f3b4a2 100644
--- a/src/node_sqlite.cc
+++ b/src/node_sqlite.cc
@@ -748,7 +748,7 @@ Intercepted DatabaseSyncLimits::LimitsGetter(
   }
 
   DatabaseSyncLimits* limits;
-  ASSIGN_OR_RETURN_UNWRAP(&limits, info.HolderV2(), Intercepted::kNo);
+  ASSIGN_OR_RETURN_UNWRAP(&limits, info.Holder(), Intercepted::kNo);
 
   Environment* env = limits->env();
   Isolate* isolate = env->isolate();
@@ -780,7 +780,7 @@ Intercepted DatabaseSyncLimits::LimitsSetter(
   }
 
   DatabaseSyncLimits* limits;
-  ASSIGN_OR_RETURN_UNWRAP(&limits, info.HolderV2(), Intercepted::kNo);
+  ASSIGN_OR_RETURN_UNWRAP(&limits, info.Holder(), Intercepted::kNo);
 
   Environment* env = limits->env();
   Isolate* isolate = env->isolate();
@@ -2945,9 +2945,9 @@ BaseObjectPtr<StatementSyncIterator> StatementExecutionHelper::Iterate(
   }
 
   if (iter->object()
-          ->GetPrototypeV2()
+          ->GetPrototype()
           .As<Object>()
-          ->SetPrototypeV2(context, js_iterator_prototype)
+          ->SetPrototype(context, js_iterator_prototype)
           .IsNothing()) {
     return BaseObjectPtr<StatementSyncIterator>();
   }
diff --git a/src/node_util.cc b/src/node_util.cc
index 8be8a8b5726a26..bf8391694f662d 100644
--- a/src/node_util.cc
+++ b/src/node_util.cc
@@ -366,7 +366,7 @@ static void DefineLazyPropertiesGetter(
   // When this getter is invoked in a vm context, the `Realm::GetCurrent(info)`
   // returns a nullptr and retrieve the creation context via `this` object and
   // get the creation Realm.
-  Local<Value> receiver_val = info.HolderV2();
+  Local<Value> receiver_val = info.Holder();
   if (!receiver_val->IsObject()) {
     THROW_ERR_INVALID_INVOCATION(isolate);
     return;
diff --git a/src/node_webstorage.cc b/src/node_webstorage.cc
index de899e25fe056c..bb1ec9338114cf 100644
--- a/src/node_webstorage.cc
+++ b/src/node_webstorage.cc
@@ -562,7 +562,7 @@ template <typename T>
 static bool ShouldIntercept(Local<Name> property,
                             const PropertyCallbackInfo<T>& info) {
   Environment* env = Environment::GetCurrent(info);
-  Local<Value> proto = info.HolderV2()->GetPrototypeV2();
+  Local<Value> proto = info.Holder()->GetPrototype();
 
   if (proto->IsObject()) {
     bool has_prop;
@@ -586,7 +586,7 @@ static Intercepted StorageGetter(Local<Name> property,
   }
 
   Storage* storage;
-  ASSIGN_OR_RETURN_UNWRAP(&storage, info.HolderV2(), Intercepted::kNo);
+  ASSIGN_OR_RETURN_UNWRAP(&storage, info.Holder(), Intercepted::kNo);
   Local<Value> result;
 
   if (storage->Load(property).ToLocal(&result) && !result->IsNull()) {
@@ -600,7 +600,7 @@ static Intercepted StorageSetter(Local<Name> property,
                                  Local<Value> value,
                                  const PropertyCallbackInfo<Boolean>& info) {
   Storage* storage;
-  ASSIGN_OR_RETURN_UNWRAP(&storage, info.HolderV2(), Intercepted::kNo);
+  ASSIGN_OR_RETURN_UNWRAP(&storage, info.Holder(), Intercepted::kNo);
 
   if (storage->Store(property, value).IsNothing()) {
     info.GetReturnValue().SetFalse();
@@ -616,7 +616,7 @@ static Intercepted StorageQuery(Local<Name> property,
   }
 
   Storage* storage;
-  ASSIGN_OR_RETURN_UNWRAP(&storage, info.HolderV2(), Intercepted::kNo);
+  ASSIGN_OR_RETURN_UNWRAP(&storage, info.Holder(), Intercepted::kNo);
   Local<Value> result;
   if (!storage->Load(property).ToLocal(&result) || result->IsNull()) {
     return Intercepted::kNo;
@@ -629,7 +629,7 @@ static Intercepted StorageQuery(Local<Name> property,
 static Intercepted StorageDeleter(Local<Name> property,
                                   const PropertyCallbackInfo<Boolean>& info) {
   Storage* storage;
-  ASSIGN_OR_RETURN_UNWRAP(&storage, info.HolderV2(), Intercepted::kNo);
+  ASSIGN_OR_RETURN_UNWRAP(&storage, info.Holder(), Intercepted::kNo);
 
   info.GetReturnValue().Set(storage->Remove(property).IsJust());
 
@@ -638,7 +638,7 @@ static Intercepted StorageDeleter(Local<Name> property,
 
 static void StorageEnumerator(const PropertyCallbackInfo<Array>& info) {
   Storage* storage;
-  ASSIGN_OR_RETURN_UNWRAP(&storage, info.HolderV2());
+  ASSIGN_OR_RETURN_UNWRAP(&storage, info.Holder());
   Local<Array> result;
   if (!storage->Enumerate().ToLocal(&result)) {
     return;
@@ -650,7 +650,7 @@ static Intercepted StorageDefiner(Local<Name> property,
                                   const PropertyDescriptor& desc,
                                   const PropertyCallbackInfo<Boolean>& info) {
   Storage* storage;
-  ASSIGN_OR_RETURN_UNWRAP(&storage, info.HolderV2(), Intercepted::kNo);
+  ASSIGN_OR_RETURN_UNWRAP(&storage, info.Holder(), Intercepted::kNo);
 
   if (desc.has_value()) {
     return StorageSetter(property, desc.value(), info);
diff --git a/src/util-inl.h b/src/util-inl.h
index d59e30a635b08b..17f72857aa5ba4 100644
--- a/src/util-inl.h
+++ b/src/util-inl.h
@@ -811,7 +811,7 @@ inline v8::MaybeLocal<v8::Object> NewDictionaryInstanceNullProto(
     if (value.IsEmpty()) return v8::MaybeLocal<v8::Object>();
   }
   v8::Local<v8::Object> obj = tmpl->NewInstance(context, property_values);
-  if (obj->SetPrototypeV2(context, v8::Null(v8::Isolate::GetCurrent()))
+  if (obj->SetPrototype(context, v8::Null(v8::Isolate::GetCurrent()))
           .IsNothing()) {
     return v8::MaybeLocal<v8::Object>();
   }